产品说明
一般描述
A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Reduces histamine-induced calcium mobilization in C6 glioma cells. Down-regulates the activity of the serine/threonine protein kinase casein kinase II in HT29 cells.
A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protein kinase casein kinase II in HT29 cells.
包装
250 mg in Glass bottle
生化/生理作用
Primary Target
Induce apoptosis
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Irritant (B)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Ou, H.C., et al. 1997. Neuroreport 8, 1375.
Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
Krupitza, G., et al. 1995. Carcinogenesis16, 1199.
Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun.195, 31.
Hague, A., et al. 1993. Int. J. Cancer55, 498.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C4H7NaO2 |
| 分子量 | 110.09 |
| MDL编号 | MFCD00002816 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥98% (titration) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 颜色 | white |
| 溶解性 | water: 2 mg/mL |
| 运输 | ambient |
| 储存温度 | −20℃ |
| InChI | 1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1 |
| InChI key | MFBOGIVSZKQAPD-UHFFFAOYSA-M |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H302 - H314 |
| 预防措施声明 | P260 - P270 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B |
| 储存分类代码 | 8A - Combustible, corrosive hazardous materials |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
