3α-Hydroxy-3β-methyl-5α-pregnan-20-one

产品名称：

38398-32-2
Ganaxolone
3α-Hydroxy-3β-methyl-5α-pregnan-20-one
CCD 1042

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₂₂H₃₆O₂
分子量	332.52
MDL编号	MFCD00945298
PubChem化学物质编号	24724496
NACRES	NA.77

产品性质

质量水平	100
测定	(The product is pure based on elemental analysis, NMR, MS, optical rotation and melting point.) ≥98% (HPLC)
形式	solid
颜色	white
溶解性	DMSO: ≥2 mg/mL H₂O: insoluble
储存温度	2-8℃
SMILES string	[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@](C)(O)C2
InChI	1S/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1
InChI key	PGTVWKLGGCQMBR-FLBATMFCSA-N
Gene Information	human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879) mouse ... Gabrg2(14406)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable