4-氨基-2-（2,6-二氧代-3-哌啶基）-1H-异吲哚-1,3 (2H)-二酮

产品名称：

19171-19-8
Pomalidomide
3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
IMiD 3
1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
CC-4047
Actimid
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
泊马度胺
4-氨基-2-（2,6-二氧代-3-哌啶基）-1H-异吲哚-1,3 (2H)-二酮
1,3-二氧代-2-（2,6-二氧哌啶-3-基）-4-氨基异吲哚
3-氨基-N-（2,6-二氧代-3-哌啶基）苯甲酰胺

产品介绍：

产品说明

应用

Pomalidomide has been used:

to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides
for apoptosis studies and intracellular calcium analysis
as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells

包装

5, 25 mg in glass bottle

生化/生理作用

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).
泊马度胺是第二代免疫调节剂，TNF-α抑制剂和沙利度胺类似物。

特点和优势

该化合物出现在《受体分类和信号转导手册》细胞因子受体(肿瘤坏死受体家族) 页面。要浏览其他手册页，单击此处。

基本信息

经验(实验)分子式	C₁₃H₁₁N₃O₄
分子量	273.24
MDL编号	MFCD12756407
PubChem化学物质编号	329819974
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	yellow
溶解性	DMSO: ≥14 mg/mL
储存温度	2-8℃
SMILES string	Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
InChI	1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI key	UVSMNLNDYGZFPF-UHFFFAOYSA-N
Gene Information	human ... CRBN(51185), CUL4A(8451), DDB1(1642), RBX1(9978)

安全信息

象形图
警示用语：	Danger
危险声明	H360D
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 1B
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable