SD-208

产品名称：

627536-09-8
SD-208
2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine

产品介绍：

产品说明

应用

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.²

包装

5, 25 mg in glass bottle

生化/生理作用

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.¹
SD-208 is TGF-βR I kinase inhibitor with IC₅₀ =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

基本信息

经验(实验)分子式	C₁₇H₁₀ClFN₆
分子量	352.75
MDL编号	MFCD11519969
PubChem化学物质编号	24899731
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	off-white to tan
溶解性	DMSO: >5 mg/mL
储存温度	2-8℃
SMILES string	Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2
InChI	1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChI key	BERLXWPRSBJFHO-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves