TBCA

产品名称：

934358-00-6
TBCA
(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
Tetrabromocinnamic acid

产品介绍：

产品说明

应用

Tetrabromocinnamic acid (TBCA) has been used in protein-fragment complementation assay, in an approach to identify inhibitors of αsyn oligomerization.

包装

5, 25 mg in glass bottle

生化/生理作用

Tetrabromocinnamic acid (TBCA) is a selective cell-permeable ATP-competitive casein kinase CK2 inhibitor with an IC₅₀ of 110 nM, 2-fold selectivity over CK1, and with the advantage of being less active on DYRK1A (IC₅₀ = 24.5 μM) than other CK2 inhibitors suh as DMAT. Elevated levels of CK2 are associated with many cancers and also with tau hyperphosphorylation and neuropathology found in Alzheimer′s disease and other neurodegenerative disorders. In prostate cancer cells TBCA reduced cell proliferation and caused G2/M cell cycle arrest. In isolated squid axoplasms, TBCA also blocked inhibition of fast axonal transport by Aβ oligomers.

基本信息

经验(实验)分子式	C₉H₄Br₄O₂
分子量	463.74
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2