N,N′-Bis(4-amino-2-methyl-6-quinolyl)urea

产品名称：

Surfen hydrate
Aminokinuride
Aminoquinuride
1,3-Bis(4-amino-2-methyl-6-quinolyl)urea hydrate
N,N′-Bis(4-amino-2-methyl-6-quinolyl)urea
Aminoquincarbamide
NSC 12155
(bis-2-methyl-4-amino-quinolyl-6-carbamide hydrate

产品介绍：

产品说明

应用

Surfen hydrate may be used as an antagonist to heparin.
Surfen hydrate has been used in the inhibition of multiple voltage-gated calcium channels in human embryonic kidney cells.

包装

5, 25 mg in glass bottle

生化/生理作用

Surfen is a heparan sulfate antagonist, originally developed in the late thirties as an excipient for the production of depot insulin. Heparan sulfate (HS) is structurally related to heparin but contains fewer sulfate groups per disaccharide, and it exists almost exclusively attached to protein cores of proteoglycans, which cells either display on the plasma membrane or secrete into the extracellular matrix. Surfen binds to the chains of glycosaminoglycan (GAG)/HS and prevents binding of the enzymes and proteins thus act as HS antagonist. Surfen is more potent than protamine, a clinically used heparin antagonist.

基本信息

经验(实验)分子式	C₂₁H₂₀N₆O · xH₂O
分子量	372.42 (anhydrous basis)
MDL编号	MFCD17215963
PubChem化学物质编号	329824572
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O.Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1
InChI	1S/C21H20N6O.H2O/c1-11-7-17(22)15-9-13(3-5-19(15)24-11)26-21(28)27-14-4-6-20-16(10-14)18(23)8-12(2)25-20;/h3-10H,1-2H3,(H2,22,24)(H2,23,25)(H2,26,27,28);1H2
InChI key	UXYZYUHSZVKWTR-UHFFFAOYSA-N

安全信息

危险声明	H413
危险分类	Aquatic Chronic 4
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable