Monoclonal Anti-Cytokeratin Peptide 14 antibody produced in mouse

产品说明

一般描述

Monoclonal Anti-Cytokeratin Peptide 14 (mouse IgM isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Keratin 14 (KRT14) is expressed in keratinocytes and localized to the basal epidermal layer. The gene is mapped to human chromosome 17q21 and encodes an intermediate filament.

特异性

The antibody reacts with myoepithelial cells in various organs (parotid, submandibular, mammary, prostate, and sweat glands) as well as with the basal layer of certain squamous epithelium (exocervical, laryngeal epithelium).

免疫原

human callus keratins.

应用

Monoclonal Anti-Cytokeratin Peptide 14 antibody produced in mouse has been used in indirect immunofluorescence or immunoperoxidase techniques.

生化/生理作用

Keratin 14 (KRT14) is associated with maintaining cellular stability. Mutation in the KRT14 gene leads to epidermolysis bullosa simplex, a genetic disorder. It is known to promote angiogenesis, cell migration and proliferation in cancer cells.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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