(±)-β-（氨甲基）-4-氯苯丙酸

产品名称：

1134-47-0
(±)-Baclofen
(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid
Lioresal
(±)-巴氯芬
(±)-β-（氨甲基）-4-氯苯丙酸
巴氯芬片

产品介绍：

产品说明

应用

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABA_B receptor agonist:

as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
to test its effects on in vivo motor function tests and performance of mutant mice
to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
to test its effect in reducing dendritic excitability in Purkinje neurons

生化/生理作用

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABA_B) agonist, baclofen may be involved in the potentiation of dendritic potassium K⁺channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).
GABA _B 受体激动剂；骨骼肌松弛剂；解痉剂。

基本信息

经验(实验)分子式	C₁₀H₁₂ClNO₂
分子量	213.66
EC 号	214-486-9
MDL编号	MFCD00055143
PubChem化学物质编号	24278146
NACRES	NA.32

产品性质

质量水平	100
测定	≥98% (TLC)
形式	solid
颜色	white to very faintly yellow
溶解性	1 M HCl: 50 mg/mL
储存温度	2-8℃
SMILES string	ClC1=CC=C(C(CN)CC(O)=O)C=C1
InChI	1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChI key	KPYSYYIEGFHWSV-UHFFFAOYSA-N
Gene Information	human ... GABBR1(2550), GABBR2(9568) rat ... Gabbr1(81657), Gabra2(29706)

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges