H-7 dihydrochloride

产品名称：

108930-17-2
H-7 dihydrochloride
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride
Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride

产品介绍：

产品说明

一般描述

H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).

应用

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

包装

5 mg in glass bottle
25 mg in poly bottle

生化/生理作用

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.

注意

Light sensitive

基本信息

经验(实验)分子式	C₁₄H₁₇N₃O₂S · 2HCl
分子量	364.29
Beilstein	5840763
MDL编号	MFCD00036961
PubChem化学物质编号	24278496
NACRES	NA.77

产品性质

质量水平	200
测定	≥98% (HPLC)
形式	powder
溶解性	H₂O: 20 mg/mL
储存温度	2-8℃
SMILES string	Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23
InChI	1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
InChI key	OARGPFMFRLLKPF-UHFFFAOYSA-N
Gene Information	human ... PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)