产品说明
一般描述
Chemical structure: imidazole
应用
Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca2+ transport pathways in thymic lymphocytes.
生化/生理作用
Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.
基本信息
| 经验(实验)分子式 | C18H15Cl3N2O · HNO3 |
| 分子量 | 444.70 |
| EC 号 | 246-053-5 |
| MDL编号 | MFCD00058160 |
| PubChem化学物质编号 | 24894567 |
| NACRES | NA.85 |
产品性质
| 质量水平 | 200 |
| 形式 | powder or crystals |
| 颜色 | white to off-white |
| 作用机制 | cell membrane | interferes cell wall synthesis | interferes enzyme | inhibits |
| 抗生素抗菌谱 | Gram-positive bacteria fungi |
| SMILES string | O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 |
| InChI | 1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4) |
| InChI key | DDXORDQKGIZAME-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 - H315 - H319 |
| 预防措施声明 | P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
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