产品说明
应用
通过与蛋白酶形成 1:1 复合物抑制各种内切蛋白酶。当蛋白酶裂解巨球蛋白"诱饵"序列时，巨球蛋白将重排并捕获蛋白酶。
生化/生理作用
α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
分析说明
100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0
经检测，每位捐献者的血浆 HIV-1/HIV-2 抗体、HCV 和 HbSAg 抗体均为阴性。
其他说明
Conformational changes of α2-M
基本信息
| MDL编号 | MFCD00130472 |
| NACRES | NA.61 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human plasma |
| 测定 | ≥90% (GE) |
| 分子量 | ~720 kDa (four glycoprotein subunits) |
| technique(s) | cell culture | mammalian: suitable |
| 溶解性 | H2O: 1 mg/mL, clear to faintly turbid, colorless to faintly yellow |
| UniProt登记号 | P01023 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... A2M(2) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
