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Dacarbazine

达卡巴嗪

品牌
Sigma-Aldrich
CAS
4342-03-4
货号
D2390
规格纯度
antineoplastic purine analog
参考价格
716.43 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
4342-03-4
Dacarbazine
DTIC
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
达卡巴嗪
产品介绍:

产品说明

应用

Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.

包装

1 g in glass bottle
100 mg in glass bottle

生化/生理作用

Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

基本信息

经验(实验)分子式C6H10N6O
分子量182.18
EC 号224-396-1
MDL编号MFCD00057167
PubChem化学物质编号24893683
NACRESNA.85

产品性质

质量水平100
形式powder or crystals
溶解性1 M HCl: 50 mg/mL
作用机制DNA synthesis | interferes
抗生素抗菌谱neoplastics
储存温度2-8℃
SMILES stringCN(C)\N=N\c1[nH]cnc1C(N)=O
InChI1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI keyFDKXTQMXEQVLRF-ZHACJKMWSA-N

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350
预防措施声明P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Sigma-Aldrich

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