产品说明
应用
Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.
包装
1 g in glass bottle
100 mg in glass bottle
生化/生理作用
Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
基本信息
| 经验(实验)分子式 | C6H10N6O |
| 分子量 | 182.18 |
| EC 号 | 224-396-1 |
| MDL编号 | MFCD00057167 |
| PubChem化学物质编号 | 24893683 |
| NACRES | NA.85 |
产品性质
| 质量水平 | 100 |
| 形式 | powder or crystals |
| 溶解性 | 1 M HCl: 50 mg/mL |
| 作用机制 | DNA synthesis | interferes |
| 抗生素抗菌谱 | neoplastics |
| 储存温度 | 2-8℃ |
| SMILES string | CN(C)\N=N\c1[nH]cnc1C(N)=O |
| InChI | 1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+ |
| InChI key | FDKXTQMXEQVLRF-ZHACJKMWSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350 |
| 预防措施声明 | P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313 |
| 危险分类 | Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
Sigma-Aldrich
m.cnreagent.com
