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Anti-LRP1B (C-terminal region) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200326
规格纯度
~1.5 mg/mL, affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-LRP1B (C-terminal region) antibody produced in rabbit
Anti-Low density lipoprotein receptor-related protein 1B
Anti-LRPDIT
Anti-LRP-DIT
产品介绍:

产品说明

一般描述

LDL receptor-related protein 1B (LRP1B) belongs to the low-density lipoprotein (LDL) receptor gene family, including LDLR, LRPs (low density lipoprotein related proteins), megalin/GP330, VLDLR (very low density lipoprotein receptor) and ApoER2.

免疫原

synthetic peptide corresponding to a sequence near the C-terminus of human LRP1B, conjugated to KLH. The corresponding sequence is identical in mouse LRP1B.

应用

Anti-LRP1B (C-terminal region) antibody produced in rabbit has been used in:

  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

生化/生理作用

LDL receptor-related protein 1B (LRP1B) is a candidate tumor suppressor gene, that is inactivated in several types of human malignancies, including non-small cell lung cancer (NSCLC) and plays an important role in tumorigenesis. It regulates the endocytic trafficking of the β-amyloid precursor protein (APP) and reduces the production of amyloid-β peptide (Ab) involved in the pathogenesis of Alzheimer′s disease. LRP1B regulates the degradation of the platelet derived growth factor-β receptor (PDGFR-β) and is implicated in the development of atherosclerosis.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~190 kDa (Rat)
antigen ~200 kDa (Human)
species reactivityhuman, mouse, rat
浓度~1.5 mg/mL
technique(s)immunoprecipitation (IP): 5-10 μg using extracts of HEK-293T cells overexpressing human LRP1B.
indirect immunofluorescence: 1-2 μg/mL using HEK-293T cells overexpressing human LRP1B.
western blot: 1.5-3.0 μg/mL using extracts of rat brain (S1 fraction) and mouse brain (S1 fraction).
UniProt登记号Q9NZR2
运输dry ice
储存温度−20℃
Gene Informationhuman ... LRP1B(53353)
mouse ... Lrp1b(94217)
rat ... Lrp1b(311926)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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