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Anti-MAGL Antibody

品牌
Sigma-Aldrich
货号
ABN1000
规格纯度
from rabbit, purified by affinity chromatography
参考价格
5520.38 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-MAGL Antibody
Monoglyceride lipase, MGL, Monoacylglycerol lipase, MAGL
产品介绍:

产品说明

一般描述

Monoglyceride lipase (MGL), or alternatively HU-K5, Lysophospholipase homolog, Lysophospholipase-like, or Monoacylglycerol lipase (MAGL) is a protein encoded by the MGLL gene in humans and is very important in lipid metabolism. Monoglyceride lipase is the enzyme that converts monoacylglycerides (key building blocks of lipids) into free fatty acid chains and glycerol. Also, Monoglyceride Lipase hydrolyzes endocannabinoids which ultimately can regulate nociperception and the perception of pain, so the enzyme is being studied in pain mediation therapies. Monoglyceride Lipase is expressed in many tissues including fat, lung, liver, brain and heart. In disease, Monoglyceride Lipase is being studied most intensely in cancer research. In some cancers it appears to be play a suppressive role in regulating AKT mediated signaling, but in others, since the enzyme regulates the levels of fatty acids that can serve as intra and intercellular signaling molecules, Monoglyceride lipase activity seems to promote cancer cell migration, invasion and growth.

免疫原

Recombinant protein corresponding to mouse MAGL.

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MAGL in human cerebral cortex tissue.
Immunohistochemistry Analysis: A representative lot detected MAGL in human hippocampus tissue (Mulder, J., et al. (2011). Brain. 134:1041-1060).
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
This Anti-MAGL Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of MAGL.

质量

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected MAGL in 10 µg of mouse brain tissue lysate.

目标描述

~ 31/33 kDa observed. This protein can be alternatively spliced, so western blots may show a doublet. Evidence for alternative splicing of MAGL, can run as doublet, ~31 and ~33 kDa

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman, rat, mouse
technique(s)immunohistochemistry: suitable
western blot: suitable
NCBI登记号NP_001159721
UniProt登记号O35678
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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