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Anti-MUTYH antibody produced in rabbit

品牌
Sigma-Aldrich
货号
HPA008732
规格纯度
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
参考价格
2216.02 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-MUTYH antibody produced in rabbit
Anti-MutY homolog
Anti-hMYH
Anti-A/G-specific adenine DNA glycosylase
产品介绍:

产品说明

一般描述

MUTYH (mutY DNA glycosylase) is a key enzyme of the human DNA repair system. It is expressed in several isoforms, of which two are predominant- type1 mitochondrial and type2 nuclear form. This gene is localized to human chromosome 1p34.1 and spans 11.2kb.

免疫原

A/G-specific adenine DNA glycosylase recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

MUTYH (mutY DNA glycosylase) is a part of the DNA glycosylase-initiating base excision repair, where it catalyzes the excision of mispaired adenine with 8-Hydroxyguanine (8OHG) is double-stranded DNA. Biallelic germline inactivating mutations in this gene are responsible for MUTYH-associated polyposis, which results in multiple colorectal polyps and carcinoma. Studies in a Japanese patient show that p.Arg109Trp variant of this gene results in dysfunctional MUTYH enzyme. This results in early-onset colorectal cancer. Inactivation of this gene leads to genetic instability in lymphoblastoid cell lines, which is dependent on the degree of inactivation. Biallelic mutations in this gene are also responsible for Lynch-like syndrome (LLS), which is characterized by tumors containing mismatch repair (MMR) deficiency, without association with germline mutations or somatic methylation of MMR genes.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST71064.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

人类蛋白质图谱编号HPA008732    Human Protein Atlas characterization data

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
产品线Prestige Antibodies® Powered by Atlas Antibodies
形式buffered aqueous glycerol solution
species reactivityhuman
包装antibody small pack of 25 μL
增强验证recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:20-1:50
免疫原序列PDVEECAPNTGQCHLCLPPSEPWDQTLGVVNFPRKASRKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTWEPSEQLQRKALLQELQRWA
UniProt登记号Q9UIF7
运输wet ice
储存温度−20℃
Gene Informationhuman ... MUTYH(4595)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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