Anti-DPP4/CD26 antibody produced in goat

产品说明

一般描述

Dipeptidyl peptidase 4 (DPP4), also known as cluster of differentiation 26 (CD26), is localized on T- cell surface and interacts with adenosine deaminase (ADA), collagen and CD459. The gene encoding this protein is localized on human chromosome 2q24.2.

免疫原

Peptide with sequence C-PPHFDKSKKYP from the internal region of the protein sequence according to NP_001926.2.

生化/生理作用

Dipeptidyl peptidase 4 (DPP4) or CD26 plays a vital role in T cell co-stimulation, cell-to-cell adhesion and in human immunodeficiency virus (HIV) infection. It functions as a serine protease enzyme that catalyzes the cleavage of dipeptides from peptides containing proline or alanine residues. This protein is a biomarker and therapeutic target for asthma. Deletion of the DPP4 gene affects carbohydrate metabolism which in turn leads to mental retardation and hypotonia. Abnormal expression of the protein is observed during liver regeneration, cirrhosis and liver tumorigenesis. Also, DPP4 level is reduced in serum of chronic obstructive pulmonary disease (COPD) patients.

特点和优势

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外形

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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