Anti-Frizzled-1 antibody produced in rabbit

产品说明

免疫原

synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-1, conjugated KLH. The immunizing peptide has 85% homology with the rat and mouse gene.

应用

Anti-Frizzled-1 antibody is suitable for immunohistochemistry studies (formalin-fixed, paraffin-embedded sections) at a concentration of 4μg/mL, using human kidney.

生化/生理作用

Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In human, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. Frizzled 1 (FZD1) protein is an essential component of the Wnt/β-catenin pathway. It is expressed in heart, kidney, lung, ovary, pancreas, placenta, and prostate. It has been reported that, FZD1 is up-regulated in several cancers including colon, ovarian, breast neuroblastoma.

外形

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质