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Anti-NUCB2 (N-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
N9414
规格纯度
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
6784.15 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-NUCB2 (N-terminal) antibody produced in rabbit
Anti-Calnuc
Anti-Nucleobindin 2
Anti-Nesfatin
Anti-NEFA
Anti-P54
Anti-Nef
产品介绍:

产品说明

一般描述

NUCB2 (N-terminal) (nucleobindin 2, also known as NEFA, p54) belongs to the nucleobindin family of EF-hand Ca2+-binding proteins.
Nucleobindin 2 (NUCB2), contain multiple functional domains, including a Leu/Ile-rich region, a putative nuclear localization signal, a DNA binding domain, two Ca2+ -binding EF-hand motifs, and a leucine zipper region. NUCB2 is widely distributed and is localized to the Golgi apparatus. Human NUCB2 has high homology (62% sequence identity) with human NUCB1, an additional member of the nucleobindin family, although they are encoded by two separate genes.

应用

Anti-NUCB2 (N-terminal) antibody produced in rabbit has been used in:

  • immunofluorescence
  • western blotting
  • immunohistochemistry

生化/生理作用

Nucleobindin 2 (NUCB2) is implicated in various functions, including Ca2+ homeostasis, hypothalamic regulation of feeding, and tumor necrosis factor (TNF)-receptor-1 (TNFR1) shedding. NUCB2 has been shown to interact with both necdin and endoplasmic reticulum aminopeptidase 1 (ARTS-1), both through the EF-hand motif. NUCB2-ARTS-1 complex is required for the proteolytic cleavage and release of TNFR1 to the extracellular compartment. NUCB2 has been recently identified as a novel satiety molecule in the hypothalamus, associated with melanocortin signaling in the central nervous system. NUCB2 and its N-terminal 82-amino acid cleavage fragment, termed nesfatin-1, have been shown to induce suppression of food-intake in rats.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.44

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~54 kDa
species reactivitymouse, rat
浓度~1.5 mg/mL
technique(s)indirect immunofluorescence: 1-2 μg/mL using Rat2 cells
western blot: 1.5-3.0 μg/mL using Rat2 cell lysates
western blot: 2-4 μg/mL using mouse testis extracts (S1 fraction)
UniProt登记号P81117
运输dry ice
储存温度−20℃
Gene Informationrat ... Nucb2(59295)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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