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Anti-NQO1 (C-terminal) antibody produced in rabbit

Anti-NQO1 (C-terminal) 兔抗

品牌
Sigma-Aldrich
货号
N5288
规格纯度
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
5479.44 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Anti-NQO1 (C-terminal) antibody produced in rabbit
Anti-DT-diaphorase
Anti-NAD (P)H:Menadione oxidoreductase 1, dioxin-inducible 1
Anti-NAD(P)H dehydrogenase, quinone 1
Anti-Diaphorase 4
Anti-NMOR1
Anti-DIA4
Anti-NQO1 (C-terminal) 兔抗
产品介绍:

产品说明

一般描述

NADPH:quinone oxidoreductase (NQO1, DTdiaphorase) is a 2-electron reductase. NQO1 is a FAD-containing protein that exists as a homodimer. It is ubiquitously expressed.
NADPH:quinone oxidoreductase (NQO1) is an FAD containing electron reductase that regulates the detoxification of quinones obtained from the phenolic metabolites of benzene. It is a homodimeric protein that can bind either of the reducing cofactors; NADPH or NADH . NQO1 regulates chemoprotection, neuroprotection, antitumor quinones and antioxidative defense mechanisms . NQO1 may be overexpressed in breast, colon, pulmonary and hepatic tumors.

特异性

Anti-NQO1 (C-terminal) antibody is specific for rat, mouse, and human NQO1. The immunizing peptide specifically inhibits the detection of NQO1 band by immunoblotting.

免疫原

Synthetic peptide sequence corresponding to amino acid residues 261-274 of human NQO1, with N-terminal added cysteine conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat.
synthetic peptide corresponding to amino acid resudues 261-274 of human NQO1 with N-terminal added cysteine conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat.

应用

Anti-NQO1 (C-terminal) antibody produced in rabbit has been used in:

  • western blotting
  • immunoprecipitation
  • immunofluorescence


Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Anti-NQO1 (C-terminal) antibody may be used in immunological applications such as immunoprecipitation, immunofluorescence and immunoblotting (approximately 28 kDa).

生化/生理作用

NADPH:quinone oxidoreductase (NQO1, DTdiaphorase) can bioactivate certain antitumor quinones. NQO1 has a role in antioxidant defense via the generation of antioxidant forms of ubiquinone and vitamin E. High levels of NQO1 gene expression has been observed in liver and lung tumors as compared to normal tissues of the same origin.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~28 kDa
species reactivitymouse, human, rat
浓度~1 mg/mL
technique(s)immunoprecipitation (IP): 2-5 μg using whole extract of human HeLa cells
indirect immunofluorescence: 2-5 μg/mL using human HeLa cells
western blot: 0.1-0.2 μg/mL using whole extract of rat NRK cells
western blot: 0.2-0.5 μg/mL using whole extract of mouse 3T3 cells
UniProt登记号P15559
运输dry ice
储存温度−20℃
Gene Informationhuman ... NQO1(1728)
mouse ... Nqo1(18104)
rat ... Nqo1(24314)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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