产品说明
一般描述
Constitutive coactivator of PPAR-gamma-like protein 1, also known as Oxidative stress-associated Src activator or Protein FAM120A, and encoded by the gene name FAM120A or OSSA, was recently detected within the Purα-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A is highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.
特异性
This antibody will not cross-reacti with FAM120B/PGCC1.
免疫原
Epitope: N-terminus
KLH-conjugated synthetic peptide corresponding to the N-terminus of human FAM120A.
应用
Research Category
Epigenetics & Nuclear Function
Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected FAM120A in rat brain tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected FAM120A in rat brain cells.
Anti-FAM120A Antibody is an antibody against FAM120A for use in western blotting, IHC & immunofluorescence.
Research Sub Category
RNA Metabolism & Binding Proteins
质量
Evaluated by Western Blotting in SK-N-SH cell lysate.
Western Blotting Analysis: 0.5 μg/mL of this antibody detected FAM120A in SK-N-SH cell lysate.
目标描述
~130 kDa observed. Uncharacterized bands may be observed in some lysate(s).
外形
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | rat, human |
technique(s) | immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
UniProt登记号 | Q9NZB2 |
运输 | wet ice |
Gene Information | human ... FAM120A(23196) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich