ANTI-HNRNPD antibody produced in rabbit

产品说明

一般描述

HNRNPD (heterogeneous nuclear ribonucleoprotein D) is a rhythmical RNA-binding protein. It consists of two ribonucleoprotein (RNP) type RNA-binding domains (RBDs) that are responsible for binding of UUAG sequence.

免疫原

Heterogeneous nuclear ribonucleoprotein D0 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

HNRNPD (heterogeneous nuclear ribonucleoprotein D) is involved in the cryptochrome 1 (Cry1) mRNA degradation and rhythmic translation. In addition to translational control, it also contributes to the cell cycle, apoptosis, and inflammation. HNRNPD directly interacts with the 3′ untranslated region (UTR) of Cry1 for the translational regulation of Cry1 mRNA. This interaction is a vital step for rhythmic translation. After a series of interactions, HNRNPD recruits 40S ribosomal subunit to the 5′ end of mRNA to initiate the translation of Cry1 mRNA. Its expression is up-regulated in several tumors. It has been reported that HNRNPD may have important role in identification and progression of the hepatocellular carcinoma (HCC).

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST86960.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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