产品说明
一般描述
Interleukin 1 receptor associated kinase 1 (IRAK1) is a serine/threonine kinase encoded by the gene with 14 exons mapped to human chromosome xq28. The encoded protein belongs to the IRAK family. IRAK1is characterized with a death domain at its N-terminal end which is involved in protein interaction.
免疫原
The antiserum was produced against synthesized peptide derived from human IRAK1 around the phosphorylation site of Thr209.
Immunogen Range: 175-224
应用
Anti-phospho-IRAK1 (pThr209) antibody produced in rabbit has been used in immunoprecipitation assay.
生化/生理作用
Interleukin 1 receptor associated kinase 1 (IRAK1) is a vital element of the interleukin-1 receptor (IL-1R) signaling pathway. IRAK1 functions as a downstream effector molecule of the toll like receptor (TLR) signaling pathway, implicated in inflammation, autoimmunity and cancer. IRAK1 is associated with systemic lupus erythematosus (SLE) and it is overexpressed in various cancer types including lung cancer. IRAK1, is considered to be a potential therapeutic target in myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), triple-negative breast cancer (TNBC) metastasis and paclitaxel resistance. Increased expression of IRAK1 leads to head and neck squamous cell carcinomas (HNSCCs). Therefore, inhibition of IRAK1 might be a new therapeutic strategy in HNSCC.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 76 kDa |
| species reactivity | human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:40000 western blot: 1:500-1:1000 |
| NCBI登记号 | P51617 |
| UniProt登记号 | P51617 |
| application(s) | research pathology |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... IRAK1(3654) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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