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Monoclonal Anti-CACNA1D antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB5200022
规格纯度
clone S48A-9, 1 mg/mL, purified immunoglobulin
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-CACNA1D antibody produced in mouse
Anti-CACN4
Anti-CACH3
Anti-Cav1.3, S48A-9
Anti-CACNA 1D
Anti-CACNL1A2
Anti-oltage dependent L type calcium channel subunit alpha 1D
产品介绍:

产品说明

一般描述

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is expressed in many tissues and possesses six transmembrane segments, along with a loop lining the pore of the channel. The gene encoding CACNA1D is localized on human chromosome 3p14.3.

特异性

Detects ~250 kDa. No cross-reactivity against Cav1.2

免疫原

Fusion protein amino acids 859-875 of rat Cav1.3, Accession Number P27732

应用

Monoclonal Anti-CACNA1D antibody produced in mouse has been used in immunocytochemistry.

生化/生理作用

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is crucial for the functioning of the brain and in hearing. It gets activated at a fast rate and withstands high inward Ca2+ currents even at threshold voltages. CACNA1D aids in dendritic signals linked to mitochondrial stress in the brain and is important for estrogen-stimulated Ca2+ influx. Studies have shown that in atrial myocytes, the C terminus of the channel translocates to the nucleus and regulates Ca2+-activated K+ channels. CACNA1D was shown to be upregulated in endometrial cancer and its knockdown showed a reduction in cell proliferation in vitro. Mutations in the gene encoding it has been associated with aldosterone-producing adenomas (APAs), where it leads to the formation of small adenomas.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆S48A-9, monoclonal
形式buffered aqueous glycerol solution
分子量antigen predicted mol wt 250 kDa
species reactivityhuman, rat, mouse
浓度1 mg/mL
technique(s)immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型IgG2aκ
NCBI登记号NP_058994.1
UniProt登记号Q01668
运输wet ice
储存温度−20℃
Gene Informationrat ... Cacna1d(29716)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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