Anti-Cyclin A Antibody

产品名称：

产品介绍：

产品说明

一般描述

The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F.

特异性

p58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3

免疫原

peptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L)

应用

Detect Cyclin A with Anti-Cyclin A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
Research Sub Category
Cell Cycle, DNA Replication & Repair
Research Category
Epigenetics & Nuclear Function

质量

routinely evaluated by immunoblot on HeLa nuclear extract

目标描述

58kDa

外形

Protein G Chromatography
Lyophilized
Format: Purified

储存及稳定性

2 years at -20°C

分析说明

Control
Daudi cells

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

产品性质

生物来源	rabbit
质量水平	100
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	polyclonal
species reactivity	human, sheep, mouse, rat
manufacturer/tradename	Upstate^®
technique(s)	immunocytochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable
同位素/亚型	IgG
NCBI登记号	NM_001237
UniProt登记号	P20248
运输	dry ice
Gene Information	human ... CCNA2(890)

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332 - H412
预防措施声明	P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3
储存分类代码	11 - Combustible Solids
WGK	WGK 1