产品说明
一般描述
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F.
特异性
p58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3
免疫原
peptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L)
应用
Detect Cyclin A with Anti-Cyclin A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
Research Sub Category
Cell Cycle, DNA Replication & Repair
Research Category
Epigenetics & Nuclear Function
质量
routinely evaluated by immunoblot on HeLa nuclear extract
目标描述
58kDa
外形
Protein G Chromatography
Lyophilized
Format: Purified
储存及稳定性
2 years at -20°C
分析说明
Control
Daudi cells
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| species reactivity | human, sheep, mouse, rat |
| manufacturer/tradename | Upstate® |
| technique(s) | immunocytochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| 同位素/亚型 | IgG |
| NCBI登记号 | NM_001237 |
| UniProt登记号 | P20248 |
| 运输 | dry ice |
| Gene Information | human ... CCNA2(890) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 + H312 + H332 - H412 |
| 预防措施声明 | P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 |
| 危险分类 | Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
Sigma-Aldrich
m.cnreagent.com
