Anti-PRMT1 Antibody

产品说明

一般描述

The methylation of arginine is mediated by the Protein Arginine Methyl Transferase (PRMT) family of enzymes. These enzymes transfer the methyl group from S-adenosyl-Lmethionine to the guanidino nitrogen atoms of an arginine residue. Arginine methylation was found to be an important modification in signal transduction, transcription, RNA transport, and splicing. PRMT1, also known as HRMT1L2 and IR1B4, was isolated through its interaction with BTG1 and TIS21, proteins that are important in cell quiescence. PRMT1 is a 361 amino acid protein; its splicing variants differ at the N-terminus, giving rise to three isoforms of 343, 361, and 347 amino acids (variants 1, 2, and 3 respectively). Proteins involved in the metabolism of RNA are substrates for PRMT1, among them Sam68.

特异性

PRMT1 doublet

免疫原

Peptide corresponding to residues 298-318 of human protein arginine methyltransferase 1.

应用

Research Sub Category
Histones
Research Category
Epigenetics & Nuclear Function
Anti-PRMT1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of PRMT1 & has been validated in WB.

质量

routinely evaluated by immunoblot in lysates from Jurkat and 3T3/A31, NIH 3T3, HeLa, and mouse ES cells

目标描述

42-44 kDa

外形

Format: Purified
Protein A purified
0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%

储存及稳定性

2 years at -20°C

分析说明

Control
Jurkat cell lysate

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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