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Anti-Lin28 Antibody

品牌
Sigma-Aldrich
货号
09-819
规格纯度
from rabbit, purified by affinity chromatography
参考价格
5016.79 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Anti-Lin28 Antibody
Protein lin-28 homolog A, Lin-28A, Zinc finger CCHC domain-containing protein 1
产品介绍:

产品说明

一般描述

Lin28 is a developmentally regulated RNA binding protein (RBP). Its down regulation is mediated in part by Lin4 and miR-125b, the mammalian micro-RNA homolog of Lin4. It is known to be negatively regulated by retinoic acid and act as a translational enhancer by driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis by increasing the number of initiation events per mRNA molecule. Lin28 is necessary and sufficient for selectively blocking the cleavage processing of pri-let-7 miRNAs in embryonic cells. Lin28 is a negative regulator of miRNA biogenesis and may play a role in blocking miRNA-mediated differentiation in stem cells and in certain cancer. The mechanism by which miR-125b represses Lin28 in mammalian cells appears to involve reductions not only in translational efficiency, but also in mRNA abundance. Lin28 has shown to be essential for skeletal muscle differentiation through the translational upregulation of IGF2 expression. It is known to be expressed in testis, placenta, and embryonic stem (ES) cells.

特异性

Other homologies: Rat and Mouse 98% and 97% sequence homology

免疫原

Histidine-tagged recombinant protein corresponding to human Lin28.

应用

Anti-Lin28 Antibody is a Rabbit Polyclonal Antibody for detection of Lin28 also known as Protein lin-28 homolog A & has been validated in WB.

质量

Evaluated by Western Blot in NT2/D1 cell lyate.

Western Blot Analysis: 1:5,000 dilution of this antibody detected Lin28 in 10 µg of NT2/D1 cell lysate.

目标描述

~28 kDa observed

外形

Affinity purified

分析说明

Control
NT2/D1 cell lyate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman
technique(s)western blot: suitable
NCBI登记号NP_078950
UniProt登记号Q9H9Z2
运输wet ice
Gene Informationhuman ... LIN28A(79727)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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