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位置:首页 > 品牌 > Sigma-Aldrich > Anti-phospho-IRS1 (Tyr608) mouse/ (Tyr612) human Antibody

Anti-phospho-IRS1 (Tyr608) mouse/ (Tyr612) human Antibody

品牌
Sigma-Aldrich
货号
09-432
规格纯度
Upstate®, from rabbit
参考价格
6526.19 *本价格含增值税费
促销
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数量
-+
产品名称:
Anti-phospho-IRS1 (Tyr608) mouse/ (Tyr612) human Antibody
HIRS-1, Insulin Receptor Substrate 1
产品介绍:

产品说明

一般描述

Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified that differ as to tissue distribution, subcellular localization, developmental expression, binding to the insulin receptor, and interaction with SH2 domain-containing proteins. Results from targeted disruption of the IRS genes in mice have provided important clues to the functional differences among these related molecules, suggesting they play different and specific roles in vivo. The available data are consistent with the notion that IRS-1 and IRS-2 are not functionally interchangeable in tissues that are responsible for glucose production (liver), glucose uptake (skeletal muscle and adipose tissue), and insulin production (pancreatic β cells). In fact, IRS-1 appears to have its major role in skeletal muscle whereas IRS-2 appears to regulate hepatic insulin action as well as pancreatic β cell development and survival. By contrast, IRS-3 and IRS-4 genes appear to play a redundant role in the IRS signaling system. Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes.

特异性

Predicted to cross react with mouse and rat based on 100% sequence homology.
Recognizes phospho-IRS1 (Tyr608) mouse/ (Tyr612) human

免疫原

peptide corresponding to amino acids encompassing and including phosphorylated Tyr608 in mouse and Tyr612 in human of IRS1

应用

Research Category
Signaling
Research Sub Category
Insulin/Energy Signaling
Anti-phospho-IRS1 (Tyr608) mouse/ (Tyr612) human Antibody detects level of phospho-IRS1 (Tyr608) mouse/ (Tyr612) human & has been published & validated for use in WB.

质量

Evaluated by Western Blotting in Insulin treated HEK293 cell lysate.

Western Blotting Analysis: 1 mg/mL of this antibody detected phospho-IRS1 (Tyr608) mouse/ (Tyr612) in 10 µg of lysate from Insulin treated HEK293 cells.cells

目标描述

~160 kDa observed. 131.59 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外形

Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol.
Affinity purified

储存及稳定性

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity purified immunoglobulin
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman
manufacturer/tradenameUpstate®
technique(s)western blot: suitable
同位素/亚型IgG
NCBI登记号NM_005544
UniProt登记号P35568
运输dry ice
Gene Informationhuman ... IRS1(3667)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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