产品说明
一般描述
γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean, germinated rice, and in some fermented foods.
应用
γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats. It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.
包装
10 mg in autosample vial
生化/生理作用
γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions. It is crucial for the normal central nervous system (CNS) functioning. A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects. GABA might show beneficial effects on stress and sleep in humans. γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.
大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。
基本信息
| 线性分子式 | NH2(CH2)3COOH |
| 分子量 | 103.12 |
| Beilstein | 906818 |
| EC 号 | 200-258-6 |
| MDL编号 | MFCD00008226 |
| PubChem化学物质编号 | 24891025 |
| NACRES | NA.26 |
产品性质
| 质量水平 | 200 |
| 产品线 | BioXtra |
| 测定 | ≥99% |
| 形式 | powder |
| technique(s) | ligand binding assay: suitable |
| 杂质 | <0.0005% Phosphorus (P) <0.1% Insoluble matter |
| 灼烧残渣 | <0.1% |
| 颜色 | white |
| mp | 195 ℃ (dec.) (lit.) |
| 溶解性 | H2O: 0.5 M at 20 ℃, clear, colorless |
| 痕量阴离子 | chloride (Cl-): <0.04% sulfate (SO42-): <0.05% |
| 痕量阳离子 | Al: <5 mg/kg Ca: <20 mg/kg Cu: <5 mg/kg Fe: <5 mg/kg K: <50 mg/kg Mg: <50 mg/kg NH4+: <500 mg/kg Na: <70 mg/kg Pb: <10 mg/kg Zn: <5 mg/kg |
| SMILES string | NCCCC(O)=O |
| InChI | 1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) |
| InChI key | BTCSSZJGUNDROE-UHFFFAOYSA-N |
| Gene Information | human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539) rat ... Gabra1(29705), Gabra2(29706), Olr1750(294204), Slc6a1(79212), Slc6a12(50676) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
