产品说明

应用

5-Aminosalicylic acid (5-ASA) has been used:

• to synthesize 5-formyl-aminosalicylate-inulin to quantify its release during in vitro digestion and fermentation and compare the in vitro fermentation properties of the conjugated inulin to native inulin
• in cell adhesion assay to study its effects on E-cadherin glycosylation and membranous turnover
• to evaluate its effects on the neutrophilic inflammation index (NII) phenotype to study the effectiveness of the high cholesterol diet-gut inflammation (HCD-GI) platform

5-氨基水杨酸是一种适用于 ELISA 分析的过氧化物酶底物。该底物生成棕色的可溶性终产物，该产物可通过分光光度法在 450nm 处读取。加入 3N NaOH 可终止反应，然后在 550nm 处进行读取。

包装

25, 100 g in poly bottle

生化/生理作用

5-Aminosalicylic acid (5-ASA) is a first-line medicine, used to treat inflammatory bowel diseases like ulcerative colitis (UC). It has a high-efficiency rate in maintenance and induction of remission. 5-ASA is an active component of sulfasalazine and also consists of the carbohydrate polymer, inulin. It might exhibit anti-oxidant activity to lessen tissue injury. 5-ASA is vital for the prevention of T cell activation and proliferation. It negatively regulates cyclooxygenase and lipoxygenase pathways and lowers the formation of prostaglandins and leukotrienes. 5-ASA stimulates the membranous expression of E-cadherin and boosts intercellular adhesion.

基本信息

线性分子式	H2NC6H3-2-(OH)CO2H
分子量	153.14
Beilstein	2090421
EC 号	201-919-1
MDL编号	MFCD00007877
PubChem化学物质编号	24890780
NACRES	NA.83

产品性质

质量水平	200
测定	≥99%
形式	powder
颜色	off-white to gray
mp	275-280 ℃ (dec.) (lit.)
溶解性	1 M HCl: 50 mg/mL, clear, yellow to brown
储存温度	2-8℃
SMILES string	Nc1ccc(O)c(c1)C(O)=O
InChI	1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
InChI key	KBOPZPXVLCULAV-UHFFFAOYSA-N
Gene Information	human ... ALOX5(240), PPARG(5468), PTGS1(5742), PTGS2(5743)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	536.0 °F
闪点(C)	280 ℃
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves