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Ephrin-A1/Fc Chimera from mouse

品牌
Sigma-Aldrich
货号
E9902
规格纯度
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
参考价格
7948.62 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Ephrin-A1/Fc Chimera from mouse
B61
EFL-1
LERK-1
产品介绍:

产品说明

生化/生理作用

EphA1 (ephrin receptor A1) plays an essential role in development, and is involved in the guidance of axonal and cell migration in nervous system. Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same. It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target. Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri. In esophageal squamous cells, it acts as differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.
Member of ephrin ligand family that binds Eph receptor tyrosine kinases (EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7 and EphB1). Involved in pattern formation and morphogenesis. Ephrin-A1 can be detected on fetal osteoblasts, odotoblasts, chondrocytes, and squamous epithelium. Ephrin-A1 is expressed during embryonic vasculogenesis and during tumor-induced angiogenesis.

其他说明

Extracellular domain of mouse ephrin-A1 (amino acids 1-182) fused to the C-terminal 6X histidine-tagged Fc region of human IgG.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

分析说明

The biological activity is measured by its ability to bind recombinant mouse EphA2/Fc in ELISA.

基本信息

MDL编号MFCD01867530
NACRESNA.32

产品性质

质量水平200
生物来源mouse
重组expressed in NSO cells
测定>90% (SDS-PAGE)
形式lyophilized powder
效能0.16-10 ng/mL
分子量monomer calculated mol wt 46.8 kDa
50-55 kDa by SDS-PAGE (reducing)
包装pkg of 200 μg
储存条件avoid repeated freeze/thaw cycles
杂质 endotoxin, tested
UniProt登记号P20827
储存温度−20℃
Gene Informationmouse ... Efna1(13636)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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