BL-1249

产品名称：

18200-13-0
BL-1249
(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine

产品介绍：

产品说明

一般描述

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.

应用

BL-1249 has been used:

as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
as a TREK1 and TREK2 activator in mice.

包装

10, 50 mg in glass bottle

生化/生理作用

BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.
BL-1249 is a putative activator of potassium TREK-1 channel.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₇H₁₇N₅
分子量	291.35
MDL编号	MFCD08276915
PubChem化学物质编号	24724415
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
储存条件	protect from light
颜色	pink to brown
溶解性	DMSO: ~17.5 mg/mL H₂O: insoluble
储存温度	−20℃
SMILES string	C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4
InChI	1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
InChI key	YYNRZIFBTOUICE-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335 - H413
预防措施声明	P273 - P302 + P352 - P305 + P351 + P338
危险分类	Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves