Butenafine Hydrochloride

产品名称：

101827-46-7
Butenafine Hydrochloride
N-[[4-(1,1-Dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine hydrochloride
Mentax
N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochloride

产品介绍：

产品说明

一般描述

Butenafine hydrochloride is chemically known as N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride. Butenafine, a benzylamine derivative, is a new generation antimycotic compound. It is easily soluble in methanol, ethanol, dichloromethane, and chloroform, but not in water. The allyl radical in butenafine hydrochloride is substituted by a butylbenzyl group.

应用

Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-loaded nanosponges.

包装

10, 50 mg in glass bottle

生化/生理作用

Butenafine exhibits fungicidal and antimycotic activity. This fungal squalene epoxidase inhibitor serves as an effective fungicide against T. rubrum, T. mentagrophytes, Microsporum canis, Aspergillus fumigatus, Sporothrix schenckii, Candida parapsilosis, and C. albicans. It is considered more effective and rapid than other antifungal drugs at curing dermatophytosis and preventing recurrences. In humans, it is used topically to treat tinea conditions and superficial candidiasis. Butenafine is considered a promising antimycotic compound to treat tinea pedis due to its efficiency, safety profile, relapse rates, and cost-effectiveness.
Butenafine possesses antifungal property. It is a squalene epoxidase inhibitor. Butenafine can inhibit the synthesis of ergosterol needed in fungal cell membranes.

特点和优势

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₂₃H₂₇N · HCl
分子量	353.93
MDL编号	MFCD00917064
PubChem化学物质编号	329773252
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to off-white
溶解性	DMSO: ≥10 mg/mL
创始人	Schering Plough
储存温度	room temp
SMILES string	Cl.CN(Cc1ccc(cc1)C(C)(C)C)Cc2cccc3ccccc23
InChI	1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
InChI key	LJBSAUIFGPSHCN-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H312
预防措施声明	P280
危险分类	Acute Tox. 4 Dermal
储存分类代码	11 - Combustible Solids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable