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Bisantrene dihydrochloride

比生群二盐酸盐

品牌
Sigma-Aldrich
CAS
78186-34-2
货号
B4563
规格纯度
≥98% (HPLC)
参考价格
1046.75 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
78186-34-2
Bisantrene dihydrochloride
Bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-9,10-anthracenedicarboxaldehyde dihydrochloride
NSC 337766
比生群二盐酸盐
产品介绍:

产品说明

应用

Bisantrene (NSC 337766), and its derivatives are topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor.

包装

10, 50 mg in glass bottle

生化/生理作用

Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.
Bisantrene is an anthracene bishydrazone derivative, which has antitumor activity.

基本信息

经验(实验)分子式C22H22N8 ·2HCl
分子量471.39
MDL编号MFCD01743164
PubChem化学物质编号329773240
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
溶解性deionized water: 8 mg/mL
储存温度room temp
SMILES stringCl.Cl.C1CN=C(N1)N\N=C\c2c3ccccc3c(\C=N\NC4=NCCN4)c5ccccc25
InChI1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;;
InChI keyKINULKKPVJYRON-PVNXHVEDSA-N

安全信息

象形图GHS07GHS09
警示用语:Warning
危险声明H302 - H400
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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