Chlorzoxazone

产品名称：

95-25-0
Chlorzoxazone
5-Chloro-2-hydroxybenzoxazole
5-Chloro-2(3H)-benzoxazolone

产品介绍：

产品说明

应用

Chlorzoxazone may be used:

as a calcium-activated potassium (K_Ca) channel activator in patch-clamp electrophysiology to test its effect on dendritic hyperexcitability
as a substrate for cytochrome P450 2E1 (CYP2E1) enzyme in cultured human hepatocytes
as a benzimidazolone compound to test its effect on epithelial sodium (Na⁺) transport

包装

25, 100 g in poly bottle

生化/生理作用

Chlorzoxazone inhibits the multisynaptic reflex arcs primarily in the spinal cord and brain subcortical areas. It is an activator of calcium activated potassium channels and may contribute to the aortic artery relaxation in mice. Chlorzoxazone also activates the calcium-activated potassium (K_Ca) channel and small conductance calcium-activated potassium channels (SK). It is metabolized by cytochrome P450 2E1 (CYP2E1) and serves as a probe for monitoring this enzyme function.
Chlorzoxazone is a skeletal muscle relaxant.

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₇H₄ClNO₂
分子量	169.57
EC 号	202-403-9
MDL编号	MFCD00005717
PubChem化学物质编号	24277702
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (TLC)
形式	powder
颜色	white to off-white
mp	191-192 ℃ (lit.)
溶解性	DMSO: 50 mg/mL, clear
创始人	Johnson & Johnson
储存温度	room temp
SMILES string	Clc1ccc2OC(=O)Nc2c1
InChI	1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
InChI key	TZFWDZFKRBELIQ-UHFFFAOYSA-N
Gene Information	human ... KCNN4(3783)

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves