产品说明
一般描述
The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35.
生化/生理作用
IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast.
During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
外形
Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA
分析说明
The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.
基本信息
| MDL编号 | MFCD02099094 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human |
| 重组 | expressed in NSO cells |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | 0.04 μg/mL |
| 分子量 | ~36 kDa by SDS-PAGE calculated mol wt ~31 kDa |
| 包装 | pkg of 25 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | endotoxin, tested |
| UniProt登记号 | P18065 |
| 储存温度 | −20℃ |
| Gene Information | human ... IGFBP2(3485) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H319 - H332 |
| 预防措施声明 | P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 4 Inhalation - Eye Irrit. 2 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
