产品说明
包装
25, 100 units in glass bottle
生化/生理作用
Caspase 10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase 10 cleaves and activates caspases 3, 4, 6, 7, 8 and 9 which causes the proteolytic cleavage of many key proteins such as PARP. Based on gene expression studies, caspase 10 may be crucial in embryonic development. In view of its structural homology to caspase 8, the initiator caspase in death receptor-mediated apoptosis, caspase 10 may function in a similar and redundant manner.
单位定义
One unit will hydrolyze 1 nmol of the caspase substrate IETD-pNA to IETD and p-nitroaniline per hour at pH 7.2 at 37 ℃.
外形
Lyophilized powder containing 0.052% ammonium sulfate, 0.158% Tris−HCl, and 0.76% sodium chloride.
基本信息
| MDL编号 | MFCD03456342 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in E. coli |
| 测定 | >90% (SDS-PAGE) |
| 形式 | lyophilized powder |
| specific activity | 8,000 units/mg protein (Bradford) |
| 分子量 | ~30 kDa |
| 溶解性 | PBS: soluble |
| UniProt登记号 | Q92851 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... CASP10(843) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
