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Anti-CIITA antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
C3367
规格纯度
clone 7-1H, purified from hybridoma cell culture
参考价格
4915.81 *本价格含增值税费
促销
服务
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数量
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产品名称:
Anti-CIITA antibody, Mouse monoclonal
Anti-MHC Class II Transactivator
Anti-C2TA
产品介绍:

产品说明

一般描述

Monoclonal Anti-CIITA (mouse IgG1 isotype) is derived from the hybridoma 7-1H produced by the fusion of mouse myeloma cells (Sp20 cells) and splenocytes from BALB/c mice immunized with purified N-terminal recombinant CIITA, amino acids 1-350. CIITA is expressed constitutively in B lymphocytes and in immature dendritic cells, while in other cells its expression is induced by IFN-γ.

Monoclonal Anti-CIITA recognizes human1 and mouse † CIITA.
Class II transactivator protein (CIITA) protein contains an acidic region in its N-terminal with transactivation activity, that binds to proteins in the basal transcription machinery and to cAMP response element-binding protein (CREB)-binding protein (CBP). The protein contains motifs for nuclear translocation, GTP binding motif and C-terminal leucine-rich repeats. CIITA is expressed constitutively in B lymphocytes and in immature dendritic cells, while in other cells its expression is induced by IFN-γ .

应用

The antibody may be used in immunoblotting (∼130 kDa) and immunocytochemistry.

生化/生理作用

Class II transactivator protein (CIITA) interacts with specific transcription factors and creates the appropriate transcriptional scaffold required for HLA-D gene expression.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01864254
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆7-1H, monoclonal
形式buffered aqueous solution
分子量antigen ~130 kDa
species reactivitymouse, human
浓度~2 mg/mL
technique(s)immunocytochemistry: suitable
western blot: 2-4 μg/mL using total cell extract of Raji cells
同位素/亚型IgG1
UniProt登记号P33076
运输dry ice
储存温度−20℃
Gene Informationhuman ... CIITA(4261)
mouse ... Ciita(12265)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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