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位置:首页 > 品牌 > Sigma-Aldrich > Anti-CD4 (human), violetFluor® 450, clone RPA-T4 Antibody

Anti-CD4 (human), violetFluor® 450, clone RPA-T4 Antibody

品牌
Sigma-Aldrich
货号
MABF172C
规格纯度
clone RPA-T4, from mouse, violetFluor® 450
参考价格
1828.76 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Anti-CD4 (human), violetFluor® 450, clone RPA-T4 Antibody
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD antigen CD4, CD4
产品介绍:

产品说明

一般描述

The RPA-T4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The RPA-T4 antibody is widely used as a phenotypic marker for human CD4 expression, and is cross-reactive with Chimpanzee CD4. This antibody recognizes a different epitope, and thus does not block binding of the alternative Anti-Human CD4 antibody clone OKT4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065).

免疫原

Immunogen information for this antibody is proprietary information.

应用

This mouse monoclonal Anti-CD4 Antibody (human), violetFluor® 450, clone RPA-T4, Cat. No. MABF1728 is validated for use in Flow Cytometry, for the detection of CD4.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

质量

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.25 μg from a representative lot detected CD4 in one million human peripheral blood lymphocytes.

外形

Purified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Purified by size-exclusion chromatography

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.
Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

其他说明

Concentration: Please refer to lot specific datasheet.

法律信息

violetFluor is a registered trademark of Tonbo Biotechnologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物violetFluor® 450
抗体形式purified antibody
antibody product typeprimary antibodies
克隆RPA-T4, monoclonal
species reactivityhuman
technique(s)flow cytometry: suitable
UniProt登记号P01730

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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