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位置:首页 > 品牌 > Sigma-Aldrich > 1,1-二甲基-4-苯基哌嗪碘化物

1,1-Dimethyl-4-phenylpiperazinium iodide

1,1-二甲基-4-苯基哌嗪碘化物

品牌
Sigma-Aldrich
CAS
54-77-3
货号
D5891
规格纯度
≥98% (TLC or titration)
参考价格
655.94 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
54-77-3
1,1-Dimethyl-4-phenylpiperazinium iodide
DMPP
1,1-二甲基-4-苯基哌嗪碘化物
产品介绍:

产品说明

应用

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:

  • to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
  • to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
  • to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon

包装

1, 10 g in glass bottle

生化/生理作用

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C12H19IN2
分子量318.20
Beilstein3746109
EC 号200-213-0
MDL编号MFCD00011976
PubChem化学物质编号24277832
NACRESNA.77

产品性质

质量水平200
测定≥98% (TLC or titration)
mp234-238 ℃ (lit.)
溶解性H2O: 21 mg/mL
储存温度−20℃
SMILES string[I-].C[N+]1(C)CCN(CC1)c2ccccc2
InChI1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1
InChI keyXFZJGFIKQCCLGK-UHFFFAOYSA-M
Gene Informationhuman ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)
rat ... Chrna2(170945), Chrna3(25101), Chrna4(25590), Chrnb2(54239), Chrnb4(25103)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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