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Monoclonal Anti-DYNLT1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
D9944
规格纯度
~1.0 mg/mL, clone T1, purified immunoglobulin, buffered aqueous solution
参考价格
4574.61 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-DYNLT1 antibody produced in mouse
Anti-Dynein, light chain, Tctex-type 1
Anti-Tctex-1
Anti-CW-1
Anti-TCTEL1
产品介绍:

产品说明

免疫原

recombinant dynein 1 light chain-myosin basic protein fusion protein.

应用

Monoclonal Anti-DYNLT1 antibody produced in mouse is suitable for immunocytochemistry and immunoblotting at a working concentration of 8-16μg/mL using NRK total cell lysate.

生化/生理作用

Cytoplasmic dynein motor complex is responsible for minus-end, microtubule-based motile processes. It is thus involved in a wide range of eukaryotic cellular processes including trafficking of membranal vesicles, viruses and other intracellular particles. DYNLT1 is a light chain subunit of the complex that is involved in cargo binding. It binds specifically to the cytoplasmic tail of rhodopsin and links rhodopsin-bearing vesicles to the dynein motor complex for transport. The cargo is released by the disassembly of dynein complex upon phosphorylation of DYNLT1 on Ser82 residue. This process is critical for the apical delivery of membrane cargoes. It also mediates neurite extension by modulating actin dynamics and also Rac1 activity. The abundance and expression pattern of DYNLT1 in neuronal tissues may also contribute to the invasion capabilities of neurotropic viruses like poliovirus.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆T1, monoclonal
形式buffered aqueous solution
分子量antigen ~12.5 kDa
species reactivitymouse, human, bovine, rat, monkey
浓度~1.0 mg/mL
technique(s)immunocytochemistry: suitable
western blot: 8-16 μg/mL using NRK total cell lysate
同位素/亚型IgG1
UniProt登记号P63172
运输dry ice
储存温度−20℃
Gene Informationhuman ... DYNLT1(6993)
mouse ... Dynlt1(21648)
rat ... Dynlt1(83462)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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