Anti-DCDC2 (C-terminal) antibody produced in rabbit

产品说明

一般描述

Doublecortin domain-containing protein 2 (DCDC2) belongs to the doublecortin (DCX) superfamily and contains two doublecortin domains. DCDC2 is expressed in the fetal and adult central nervous system (CNS). DCDC2 gene is mapped to human chromosome 6p22.3.

特异性

Anti-DCDC2 (C-terminal) specifically recognizes human DCDC2.

应用

Anti-DCDC2 antibody produced in rabbit is suitable for western blot analysis at a working concentration of 0.5-1μg/mL using a HEK-293T cell lysate expressing human DCDC2.

生化/生理作用

DCDC2 is one of the dyslexia susceptibility genes involved in neuronal migration and other developmental processes. The DCX domain of DCDC2 binds tubulin and enhances microtubule polymerization. Several SNPs within the DCDC2 gene have been associated with dyslexia. It modulates neuronal development in the brain.
Mutations in the DCDC2 gene is implicated in non-syndromic recessive deafness DFNB66 neonatal sclerosing cholangitis (NSC) and renal-hepatic ciliopathy.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

储存及稳定性

For continuous use, store at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots at –20 ℃. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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