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Anti-Doublecortin antibody produced in rabbit

Anti-Doublecortin 兔抗

品牌
Sigma-Aldrich
货号
D9693
规格纯度
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
5600.91 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Doublecortin antibody produced in rabbit
Anti-XLIS
Anti-DCX
Anti-Doublecortex
Anti-LISX
Anti-X-linked lissencephaly
Anti-Doublecortin 兔抗
产品介绍:

产品说明

免疫原

synthetic peptide corresponding to amino acids 151-170 of human doublecortin, conjugated to KLH. The corresponding sequence is identical in rat and mouse doublecortin.

应用

Anti-Doublecortin antibody produced in rabbit is suitable for immunoblotting at a working concentration of 1-2μg/mL using HEK-293T cells expressing human doublecortin, and mouse brain and rat brain extract (S1 fraction).
Anti-Doublecortin antibody produced in rabbit has been used in immunoblotting and immunohistofluorescence.

生化/生理作用

Doublecortin is a 40kDa microtubule-associated protein (MAP) that is essential for migration of neurons during the development of the cerebral cortex. Mutations in the human DCX gene cause lissencephaly (smooth brain) or subcortical laminar heterotopia (SCLH), characterized by mental retardation and seizures. DCX interaction with MAPs stabilizes microtubules (MTs). The interaction with MTs is via a conserved N-terminal doublecortin (DC) domain. DCX can be regulated by phosphorylation at multiple sites by several kinases, including JNK, Cdk5, PKA, and MARK/PAR-1 family of protein kinases.

外形

Solution in 0.01 M phophate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD03454961

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~40 kDa
species reactivitymouse, human, rat
增强验证recombinant expression
Learn more about Antibody Enhanced Validation
浓度~1 mg/mL
technique(s)western blot: 1-2 μg/mL using HEK-293T cells expressing human doublecortin. Also, mouse and rat brain extract (S1 fraction).
UniProt登记号O43602
运输dry ice
储存温度−20℃
Gene Informationhuman ... DCX(1641)
mouse ... Dcx(13193)
rat ... Dcx(84394)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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