产品说明
应用
Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes . DPP7 is used to study the regulation of cell quiescence . Like DPP4, DPP7 may be useful in diabetes and vascular disease research .
生化/生理作用
DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 . DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.
物理属性
Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa
单位定义
One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg ℃
外形
Supplied as a solution in 25 mM Tris-HCl, pH 8.0, 130 mM NaCl, 0.05% Tween-20, 10% glycerol
基本信息
| 酶学委员会(EC)编号 | 3.4.14.- |
| NACRES | NA.54 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in Sf9 cells |
| 形式 | solution |
| specific activity | ≥1,500 units/μg protein ≥1500 units/μg protein |
| 分子量 | 89.1 kDa |
| 相关疾病 | diabetes; cardiovascular diseases |
| 运输 | dry ice |
| 储存温度 | −70℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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