产品说明
特异性
The epitope is highly conserved in human, swine, bovine and chicken ET-A.
免疫原
synthetic peptide corresponding to amino acids 413-426 of rat ET-A (with additional N-terminal cysteine).
应用
Anti-Endothelin Receptor A antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 using rat brain sections or rat lung paraffin embedded sections and western blotting at a dilution of 1:200 using rat brain membranes and ECL.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
生化/生理作用
Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETAR mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.
外形
Lyophilized from a solution of phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
MDL编号 | MFCD01092540 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
偶联物 | unconjugated |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | lyophilized powder |
species reactivity | human, pig, bovine, chicken |
technique(s) | immunohistochemistry: 1:100 using rat brain sections or rat lung paraffin embedded sections western blot: 1:200 using rat brain membranes and ECL |
UniProt登记号 | P25101 |
运输 | dry ice |
储存温度 | −20℃ |
Gene Information | human ... EDNRA(1909) rat ... Ednra(24326) |
安全信息
危险声明 | H412 |
预防措施声明 | P273 |
危险分类 | Aquatic Chronic 3 |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich