产品说明
一般描述
Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.4
应用
Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.1 It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.2
生化/生理作用
Used for the detection of anti-PR3 auto-antibodies in immunoassays.
Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.3
外形
Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride
基本信息
| 酶学委员会(EC)编号 | 3.4.21.76 ( BRENDA | IUBMB ) |
| MDL编号 | MFCD03458212 |
| NACRES | NA.54 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥95% (PAGE) |
| 形式 | buffered aqueous solution |
| UniProt登记号 | P24158 |
| 储存温度 | −20℃ |
| Gene Information | human ... PRTN3(5657) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
