产品说明
一般描述
Chemical structure: peptide
生化/生理作用
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.
Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.
基本信息
| MDL编号 | MFCD00146824 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in Saccharomyces cerevisiae |
| 测定 | >90% (by MS, HPLC and SDS-PAGE) |
| 形式 | powder |
| 效能 | 1.7 x 10-10 M Ki (human leukocyte elastase) 4.2 x 10-10 M Ki (human proteinase 3) |
| 分子量 | ~6 kDa |
| 作用机制 | enzyme | inhibits |
| UniProt登记号 | P19957 |
| 抗生素抗菌谱 | Gram-negative bacteria Gram-positive bacteria |
| 运输 | ambient |
| 储存温度 | −20℃ |
| Gene Information | human ... PI3(5266) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
