Anti-S1P₂, C-Terminal antibody produced in rabbit

产品说明

免疫原

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-5/S1P₂ receptor.

应用

Anti-S1P₂, C-Terminal antibody produced in rabbit is suitable for western blotting.

生化/生理作用

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodeing a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

外形

Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.

基本信息

产品性质