产品说明
应用
Phosphodiesterase (PDE) is an enzyme that is used to breaks phosphodiester bonds. PDE5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. PDE5 is used to find novel PDE5 inhibitors .
生化/生理作用
PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis .
物理属性
N-terminal GST-tagged 126 kDa full-length protein
单位定义
One unit will convert 1.0 picomole of 3′,5′-cGMP to 5′-GMP per minute at pH 7.4 at 37 ℃.
外形
Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN® 20 and 3 mM DTT
法律信息
TWEEN is a registered trademark of Croda International PLC
基本信息
| 酶学委员会(EC)编号 | 3.1.4.25 ( BRENDA | IUBMB ) |
| NACRES | NA.54 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in Sf9 cells |
| 形式 | solution |
| specific activity | ≥2,000 unit/μg protein |
| 分子量 | 126 kDa |
| UniProt登记号 | O76074 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... PDE5A(8654) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
