产品说明
应用
Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).
包装
10, 100 mg in glass bottle
生化/生理作用
Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.
Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates
基本信息
| 经验(实验)分子式 | C2H6Na2O7P2 · xH2O |
| 分子量 | 249.99 (anhydrous basis) |
| EC 号 | 231-025-7 |
| MDL编号 | MFCD00152567 |
| PubChem化学物质编号 | 329820220 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥97% (NMR) |
| 形式 | solid |
| 颜色 | white |
| mp | >300 ℃ |
| 溶解性 | H2O: ≥10 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O |
| InChI | 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2 |
| InChI key | GWBBVOVXJZATQQ-UHFFFAOYSA-L |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
