产品说明
一般描述
CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons.
生化/生理作用
CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)-dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease. In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD.
Leukocyte chemoattractant protein and member of the chemokine superfamily possessing a CX3C motif. Mouse fractalkine is chemotactic for neutrophils and T-lymphocytes but not monocytes.
外形
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.
分析说明
The biological activity is measured by its ability to chemoattract freshly isolated peripheral blood lymphocytes.
基本信息
| MDL编号 | MFCD01635336 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 重组 | expressed in E. coli |
| 测定 | >97% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | 0.3-3 μg/mL |
| 分子量 | calculated mol wt ~9.5 kDa |
| 包装 | pkg of 25 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| 杂质 | endotoxin, tested |
| UniProt登记号 | O35188 |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Cx3cl1(20312) |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H315 - H318 |
| 预防措施声明 | P280 - P305 + P351 + P338 |
| 危险分类 | Eye Dam. 1 - Skin Irrit. 2 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
